circLARP4 induces cellular senescence through regulating miR-761/RUNX3/p53/p21 signaling in hepatocellular carcinoma.

Chen, Zhiqiang; Zuo, Xueliang; Pu, Liyong; Zhang, Yao; Han, Guoyong; Zhang, Long; Wu, Jindao; Wang, Xuehao

Chen, Zhiqiang; Zuo, Xueliang; Pu, Liyong; Zhang, Yao; Han, Guoyong; Zhang, Long; Wu, Jindao; Wang, Xuehao.

Afiliação

Chen Z; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation, Nanjing, China.
Zuo X; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation, Nanjing, China.
Pu L; Department of Gastrointestinal Surgery, The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College, Wuhu, China.
Zhang Y; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation, Nanjing, China.
Han G; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation, Nanjing, China.
Zhang L; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation, Nanjing, China.
Wu J; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation, Nanjing, China.
Wang X; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation, Nanjing, China.

Cancer Sci ; 110(2): 568-581, 2019 Feb.

Article em En | MEDLINE | ID: mdl-30520539

Assuntos

Autoantígenos/metabolismo; Carcinoma Hepatocelular/genética; Senescência Celular/genética; Neoplasias Hepáticas/genética; RNA/genética; Ribonucleoproteínas/metabolismo; Transdução de Sinais/genética; Animais; Pontos de Checagem do Ciclo Celular/genética; Linhagem Celular Tumoral; Proliferação de Células/genética; Subunidade alfa 3 de Fator de Ligação ao Core/genética; Inibidor de Quinase Dependente de Ciclina p21/genética; Regulação para Baixo/genética; Regulação Neoplásica da Expressão Gênica/genética; Genes Supressores de Tumor/fisiologia; Células Hep G2; Humanos; Masculino; Camundongos; Camundongos Nus; MicroRNAs; RNA Circular; Proteína Supressora de Tumor p53/genética; Antígeno SS-B

Palavras-chave

RUNX3; circLARP4; hepatocellular carcinoma; microRNA; senescence

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ribonucleoproteínas / Autoantígenos / RNA / Transdução de Sinais / Senescência Celular / Carcinoma Hepatocelular / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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