Predicting Progression to Mild Cognitive Impairment.
Ann Neurol
; 85(1): 155-160, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-30521086
ABSTRACT
Despite much attention to the use of biomarkers for predicting Alzheimer disease, little information is available at the individual level. We used the population-based Mayo Clinic Study of Aging to estimate absolute risk of cognitive impairment by biomarker group. Risk increased with age and any biomarker abnormality. For example, a 75-year-old with abnormal amyloid and cortical thinning biomarkers has about a 20% chance of cognitive impairment by age 80 years, whereas with normal biomarkers the chance is <10%. Persons with only one abnormal biomarker had similar intermediate risks. ANN NEUROL 2019;85155-160.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
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Progressão da Doença
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Disfunção Cognitiva
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article