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Predicting Progression to Mild Cognitive Impairment.
Petersen, Ronald C; Lundt, Emily S; Therneau, Terry M; Weigand, Stephen D; Knopman, David S; Mielke, Michelle M; Roberts, Rosebud O; Lowe, Val J; Machulda, Mary M; Kremers, Walter K; Geda, Yonas E; Jack, Clifford R.
Afiliação
  • Petersen RC; Department of Neurology, Mayo Clinic, Rochester, MN.
  • Lundt ES; Department of Health Sciences Research, Mayo Clinic, Rochester, MN.
  • Therneau TM; Department of Health Sciences Research, Mayo Clinic, Rochester, MN.
  • Weigand SD; Department of Health Sciences Research, Mayo Clinic, Rochester, MN.
  • Knopman DS; Department of Health Sciences Research, Mayo Clinic, Rochester, MN.
  • Mielke MM; Department of Neurology, Mayo Clinic, Rochester, MN.
  • Roberts RO; Department of Health Sciences Research, Mayo Clinic, Rochester, MN.
  • Lowe VJ; Department of Health Sciences Research, Mayo Clinic, Rochester, MN.
  • Machulda MM; Department of Radiology, Mayo Clinic, Rochester, MN.
  • Kremers WK; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN.
  • Geda YE; Department of Health Sciences Research, Mayo Clinic, Rochester, MN.
  • Jack CR; Department of Psychiatry and Psychology, Mayo Clinic, Phoenix, AZ.
Ann Neurol ; 85(1): 155-160, 2019 01.
Article em En | MEDLINE | ID: mdl-30521086
ABSTRACT
Despite much attention to the use of biomarkers for predicting Alzheimer disease, little information is available at the individual level. We used the population-based Mayo Clinic Study of Aging to estimate absolute risk of cognitive impairment by biomarker group. Risk increased with age and any biomarker abnormality. For example, a 75-year-old with abnormal amyloid and cortical thinning biomarkers has about a 20% chance of cognitive impairment by age 80 years, whereas with normal biomarkers the chance is <10%. Persons with only one abnormal biomarker had similar intermediate risks. ANN NEUROL 2019;85155-160.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Progressão da Doença / Disfunção Cognitiva Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Progressão da Doença / Disfunção Cognitiva Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article