Nicotinamide ribose ameliorates cognitive impairment of aged and Alzheimer's disease model mice.

Xie, Xian; Gao, Yi; Zeng, Min; Wang, Yi; Wei, Tao-Feng; Lu, Yun-Bi; Zhang, Wei-Ping

Xie, Xian; Gao, Yi; Zeng, Min; Wang, Yi; Wei, Tao-Feng; Lu, Yun-Bi; Zhang, Wei-Ping.

Afiliação

Xie X; Department of Pharmacology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang University School of Medicine, Zhejiang, 310058, Hangzhou, China.
Gao Y; Hospital of Stomatology, Zhejiang University School of Medicine, Hangzhou, China.
Zeng M; Department of Pharmacology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang University School of Medicine, Zhejiang, 310058, Hangzhou, China.
Wang Y; Department of Pharmacology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang University School of Medicine, Zhejiang, 310058, Hangzhou, China.
Wei TF; Department of Pharmacology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang University School of Medicine, Zhejiang, 310058, Hangzhou, China.
Lu YB; Department of Pharmacology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang University School of Medicine, Zhejiang, 310058, Hangzhou, China.
Zhang WP; Department of Pharmacology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang University School of Medicine, Zhejiang, 310058, Hangzhou, China.

Metab Brain Dis ; 34(1): 353-366, 2019 02.

Article em En | MEDLINE | ID: mdl-30523581

Assuntos

Doença de Alzheimer/tratamento farmacológico; Cognição/efeitos dos fármacos; Disfunção Cognitiva/tratamento farmacológico; Niacinamida/análogos & derivados; Doença de Alzheimer/metabolismo; Doença de Alzheimer/psicologia; Peptídeos beta-Amiloides/metabolismo; Precursor de Proteína beta-Amiloide/metabolismo; Animais; Astrócitos/efeitos dos fármacos; Astrócitos/metabolismo; Encéfalo/efeitos dos fármacos; Encéfalo/metabolismo; Disfunção Cognitiva/metabolismo; Disfunção Cognitiva/psicologia; Modelos Animais de Doenças; Memória/efeitos dos fármacos; Camundongos; Microglia/efeitos dos fármacos; Microglia/metabolismo; Atividade Motora/efeitos dos fármacos; Niacinamida/farmacologia; Niacinamida/uso terapêutico; Nicotinamida Fosforribosiltransferase/sangue; Compostos de Piridínio

Palavras-chave

Alzheimer's disease (AD); Cognition; Dementia; Neuroinflammation; Nicotinamide adenine dinucleotide (NAD); Nicotinamide ribose (NR)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Niacinamida / Cognição / Doença de Alzheimer / Disfunção Cognitiva Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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