Inflammatory Bowel Disease and the Risk of Prostate Cancer.
Eur Urol
; 75(5): 846-852, 2019 05.
Article
em En
| MEDLINE
| ID: mdl-30528221
ABSTRACT
BACKGROUND:
There are limited data examining the risk of prostate cancer (PCa) in patients with inflammatory bowel disease (IBD).OBJECTIVE:
To compare the incidence of PCa between men with and those without IBD. DESIGN, SETTING, ANDPARTICIPANTS:
This was a retrospective, matched-cohort study involving a single academic medical center and conducted from 1996 to 2017. Male patients with IBD (cases=1033) were randomly matched 19 by age and race to men without IBD (controls=9306). All patients had undergone at least one prostate-specific antigen (PSA) screening test. OUTCOME MEASUREMENTS AND STATISTICALANALYSIS:
Kaplan-Meier and multivariable Cox proportional hazard models, stratified by age and race, evaluated the relationship between IBD and the incidence of any PCa and clinically significant PCa (Gleason grade group ≥2). A mixed-effect regression model assessed the association of IBD with PSA level. RESULTS ANDLIMITATIONS:
PCa incidence at 10yr was 4.4% among men with IBD and 0.65% among controls (hazard ratio [HR] 4.84 [3.34-7.02] [3.19-6.69], p<0.001). Clinically significant PCa incidence at 10yr was 2.4% for men with IBD and 0.42% for controls (HR 4.04 [2.52-6.48], p<0.001). After approximately age 60, PSA values were higher among patients with IBD (fixed-effect interaction of age and patient group p=0.004). Results are limited by the retrospective nature of the analysis and lack of external validity.CONCLUSIONS:
Men with IBD had higher rates of clinically significant PCa when compared with age- and race-matched controls. PATIENTSUMMARY:
This study of over 10000 men treated at a large medical center suggests that men with inflammatory bowel disease may be at a higher risk of prostate cancer than the general population.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
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Doenças Inflamatórias Intestinais
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Antígeno Prostático Específico
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article