Activation of PERK-eIF2&#945;-ATF4-CHOP axis triggered by excessive ER stress contributes to lead-induced nephrotoxicity.

Wang, Min-Ge; Fan, Rui-Feng; Li, Wen-Hui; Zhang, Dong; Yang, Du-Bao; Wang, Zhen-Yong; Wang, Lin

Activation of PERK-eIF2α-ATF4-CHOP axis triggered by excessive ER stress contributes to lead-induced nephrotoxicity.

Wang, Min-Ge; Fan, Rui-Feng; Li, Wen-Hui; Zhang, Dong; Yang, Du-Bao; Wang, Zhen-Yong; Wang, Lin.

Afiliação

Wang MG; College of Animal Science and Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai'an City, Shandong Province 271018, China; Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, 61 Daizong Street, Ta
Fan RF; College of Animal Science and Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai'an City, Shandong Province 271018, China; Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, 61 Daizong Street, Ta
Li WH; College of Animal Science and Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai'an City, Shandong Province 271018, China; Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, 61 Daizong Street, Ta
Zhang D; Shandong Provincial Center for Animal Disease Control and Prevention, Ji'nan City, Shandong Province 250022, China.
Yang DB; College of Animal Science and Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai'an City, Shandong Province 271018, China; Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, 61 Daizong Street, Ta
Wang ZY; College of Animal Science and Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai'an City, Shandong Province 271018, China; Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, 61 Daizong Street, Ta
Wang L; College of Animal Science and Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai'an City, Shandong Province 271018, China; Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, 61 Daizong Street, Ta

Biochim Biophys Acta Mol Cell Res ; 1866(4): 713-726, 2019 04.

Article em En | MEDLINE | ID: mdl-30528975

Assuntos

Estresse do Retículo Endoplasmático; Túbulos Renais Proximais/efeitos dos fármacos; Chumbo/toxicidade; eIF-2 Quinase/metabolismo; Fator 4 Ativador da Transcrição/metabolismo; Animais; Apoptose/efeitos dos fármacos; Autofagia/efeitos dos fármacos; Células Cultivadas; Estresse do Retículo Endoplasmático/efeitos dos fármacos; Fator de Iniciação 2 em Eucariotos/metabolismo; Túbulos Renais Proximais/enzimologia; Túbulos Renais Proximais/metabolismo; Fenilbutiratos/farmacologia; Ratos Sprague-Dawley; Fator de Transcrição CHOP/metabolismo; Tunicamicina/farmacologia; eIF-2 Quinase/genética

Palavras-chave

Apoptosis; Autophagy; Lead; PERK-eIF2α-ATF4-CHOP pathway; Proximal tubular cells

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: EIF-2 Quinase / Estresse do Retículo Endoplasmático / Túbulos Renais Proximais / Chumbo Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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