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Oral Antibiotics Reduce Intestinal Necrosis in Acute Mesenteric Ischemia: A Prospective Cohort Study.
Nuzzo, Alexandre; Maggiori, Leon; Paugam-Burtz, Catherine; Cazals-Hatem, Dominique; Ronot, Maxime; Huguet, Audrey; Becq, Aymeric; Castier, Yves; Weiss, Emmanuel; Plessier, Aurélie; Tran-Dinh, Alexy; Joly, Francisca; Panis, Yves; Bouhnik, Yoram; Gault, Nathalie; Corcos, Olivier.
Afiliação
  • Nuzzo A; APHP, Department of Gastroenterology, IBD and Intestinal Failure, Beaujon Hospital, 92110, Clichy, France.
  • Maggiori L; DHU Unity, Paris 7 Diderot university, Sorbonne Paris Cite, 75013, Paris, France.
  • Paugam-Burtz C; APHP, Department of Colorectal Surgery, Beaujon Hospital, 92110, Clichy, France.
  • Cazals-Hatem D; DHU Unity, Paris 7 Diderot university, Sorbonne Paris Cite, 75013, Paris, France.
  • Ronot M; APHP, Department of Anesthesia and Intensive Care, Beaujon Hospital, 92110, Clichy, France.
  • Huguet A; DHU Unity, Paris 7 Diderot university, Sorbonne Paris Cite, 75013, Paris, France.
  • Becq A; APHP, Department of Surgery, Bichat Hospital, 75018, Paris, France.
  • Castier Y; DHU Unity, Paris 7 Diderot university, Sorbonne Paris Cite, 75013, Paris, France.
  • Weiss E; APHP, Department of Radiology, Beaujon Hospital, 92110, Clichy, France.
  • Plessier A; DHU Unity, Paris 7 Diderot university, Sorbonne Paris Cite, 75013, Paris, France.
  • Tran-Dinh A; APHP, Department of Gastroenterology, IBD and Intestinal Failure, Beaujon Hospital, 92110, Clichy, France.
  • Joly F; DHU Unity, Paris 7 Diderot university, Sorbonne Paris Cite, 75013, Paris, France.
  • Panis Y; APHP, Department of Gastroenterology, IBD and Intestinal Failure, Beaujon Hospital, 92110, Clichy, France.
  • Bouhnik Y; APHP, Department of Vascular Surgery, Bichat Hospital, 75018, Pairs, France.
  • Gault N; APHP, Department of Anesthesia and Intensive Care, Beaujon Hospital, 92110, Clichy, France.
  • Corcos O; DHU Unity, Paris 7 Diderot university, Sorbonne Paris Cite, 75013, Paris, France.
Am J Gastroenterol ; 114(2): 348-351, 2019 02.
Article em En | MEDLINE | ID: mdl-30538292
OBJECTIVES: To identify treatments likely to prevent progression towards irreversible transmural intestinal necrosis (ITIN) in acute mesenteric ischemia (AMI). METHODS: Prospective observational cohort study from a French intestinal stroke center. Multivariate analysis using a time-dependent Cox regression model. RESULTS: Between 2009 and 2015, 67 patients with AMI were included. ITIN occurred in 34% of patients and mortality was 13%. Oral antibiotics was independently associated with a decreased risk of ITIN (HR: 0.16 (95% CI = 0.03-0.62); p = 0.01). CONCLUSIONS: By decreasing luminal bacterial load and translocation, oral antibiotics in addition to early revascularization might reduce progression of AMI to ITIN.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Isquemia Mesentérica / Intestinos / Oclusão Vascular Mesentérica / Antibacterianos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Isquemia Mesentérica / Intestinos / Oclusão Vascular Mesentérica / Antibacterianos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article