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Chemoenzymatic Dynamic Kinetic Resolution of Amines in Fully Continuous-Flow Mode.
Farkas, Emese; Oláh, Márk; Földi, Attila; Kóti, János; Éles, János; Nagy, József; Gal, Cristian Andrei; Paizs, Csaba; Hornyánszky, Gábor; Poppe, László.
Afiliação
  • Farkas E; Department of Organic Chemistry and Technology , Budapest University of Technology and Economics , Muegyetem rkp. 3 , H-1111 Budapest , Hungary.
  • Oláh M; Department of Organic Chemistry and Technology , Budapest University of Technology and Economics , Muegyetem rkp. 3 , H-1111 Budapest , Hungary.
  • Földi A; Department of Organic Chemistry and Technology , Budapest University of Technology and Economics , Muegyetem rkp. 3 , H-1111 Budapest , Hungary.
  • Kóti J; Gedeon Richter Plc. , P.O. Box 27 , H-1475 Budapest , Hungary.
  • Éles J; Gedeon Richter Plc. , P.O. Box 27 , H-1475 Budapest , Hungary.
  • Nagy J; Department of Organic Chemistry and Technology , Budapest University of Technology and Economics , Muegyetem rkp. 3 , H-1111 Budapest , Hungary.
  • Gal CA; Biocatalysis and Biotransformation Research Centre, Faculty of Chemistry and Chemical Engineering , Babes-Bolyai University of Cluj-Napoca , Arany János str. 11 , RO-400028 Cluj-Napoca , Romania.
  • Paizs C; Biocatalysis and Biotransformation Research Centre, Faculty of Chemistry and Chemical Engineering , Babes-Bolyai University of Cluj-Napoca , Arany János str. 11 , RO-400028 Cluj-Napoca , Romania.
  • Hornyánszky G; Department of Organic Chemistry and Technology , Budapest University of Technology and Economics , Muegyetem rkp. 3 , H-1111 Budapest , Hungary.
  • Poppe L; SynBiocat LLC. , Szilasliget u. 3 , H-1172 Budapest , Hungary.
Org Lett ; 20(24): 8052-8056, 2018 12 21.
Article em En | MEDLINE | ID: mdl-30543299
ABSTRACT
In this study, lipase-mediated dynamic kinetic resolution (DKR) of various benzylic amines (1a-g) is presented which is realized in a so far unprecedented fully continuous-flow system. The DKR process applying sol-gel immobilized lipase B from Candida antarctica as biocatalyst, palladium on 3-aminopropyl-functionalized silica as racemization catalyst, isopropyl 2-ethoxyacetate as acylating agent, ammonium formate as hydrogen and nitrogen sources, and 2-methyl-2-butanol as solvent under regulated pressure provided the desired products in moderate to good yields with excellent enantiomeric excesses.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Termodinâmica / Aminas Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Termodinâmica / Aminas Idioma: En Ano de publicação: 2018 Tipo de documento: Article