Adverse Drug Reactions in Paediatric In-Patients in a South African Tertiary Hospital.
J Trop Pediatr
; 65(4): 389-396, 2019 08 01.
Article
em En
| MEDLINE
| ID: mdl-30544245
ABSTRACT
BACKGROUND:
The prevalence of adverse drug reaction (ADR) rates in children in sub-Saharan Africa is unknown.OBJECTIVES:
To describe the prevalence of ADRs in paediatric in-patients at a tertiary hospital in South Africa.METHODS:
This is a prospective study during a 3-month study period. Data collected included age, sex, diagnosis, medicines received and ADRs experienced. Causality were assessed, using the 10-question Naranjo probability scale and classified according to the Hartwig severity scale.RESULTS:
There were 61 ADRs in 18.4% (52 of 282) of patients. Median age of patients was 1.4 years (interquartile range 0.5-5.3 years). ADR was the primary admission reason in 31%. The majority of the ADRs were moderate 45.9% (28 of 61), and only 11.5% severe (7 of 61). Paediatric oncology patients suffered significantly more ADRs (56.5%; 13 of 23) [odds ratio 7.3 (3.0-17.9), p < 0.01], followed by HIV-infected patients (42.9%; 9 of 21).CONCLUSION:
The prevalence of ADRs was 18.4%, while 31% was the reason for admission.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
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Centros de Atenção Terciária
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Pacientes Internados
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
País como assunto:
Africa
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article