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In vitro activity of EDTA and TOL-463 against Neisseria gonorrhoeae.
Nash, Evelyn E; Henning, Tara C; Pham, Cau D; Pettus, Kevin; Sharpe, Samera; Kersh, Ellen N.
Afiliação
  • Nash EE; Division of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA, USA. Electronic address: lmq5@cdc.gov.
  • Henning TC; Division of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA, USA.
  • Pham CD; Division of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA, USA.
  • Pettus K; Division of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA, USA.
  • Sharpe S; Division of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA, USA.
  • Kersh EN; Division of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA, USA.
Diagn Microbiol Infect Dis ; 93(4): 369-371, 2019 Apr.
Article em En | MEDLINE | ID: mdl-30552033
ABSTRACT
Neisseria gonorrhoeae quickly develops drug resistance. Time-kill curves revealed that EDTA and TOL-463 inhibit growth similar to penicillin, ciprofloxacin, and azithromycin. Furthermore, synergistic and additive antimicrobial interactions occurred when EDTA and TOL-463 were combined with penicillin or azithromycin, respectively, suggesting that further investigations into these unconventional antimicrobials may be advantageous.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos Bóricos / Ácido Edético / Antibacterianos / Neisseria gonorrhoeae Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos Bóricos / Ácido Edético / Antibacterianos / Neisseria gonorrhoeae Idioma: En Ano de publicação: 2019 Tipo de documento: Article