Mitochondria and the aging process.
Nihon Rinsho
; 74(9): 1456-1460, 2016 Sep.
Article
em Ja
| MEDLINE
| ID: mdl-30557476
ABSTRACT
Mitochondrion is an organelle that plays major roles in energy metabolism, which is regu- lated by three mitochondrial products of the Sirtuin genes. The energy metabolism accom- panies the sub-production of reactive oxygen species, which may damage mitochondrion itself, its own DNA and various cell components by oxidation, but which function as physiologi- cally important signal molecules. Damaged mitochondria are removed by mitophagy to main- tain the quality of mitochondria. Mitochondrion plays essential roles in innate immunity. Mitochondrion exerts a multiple function to be involved in the aging process.
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Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Espécies Reativas de Oxigênio
/
Mitocôndrias
Limite:
Animals
/
Humans
Idioma:
Ja
Ano de publicação:
2016
Tipo de documento:
Article