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Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy.
Whitney, James B; Lim, So-Yon; Osuna, Christa E; Kublin, Jessica L; Chen, Elsa; Yoon, Gyeol; Liu, Po-Ting; Abbink, Peter; Borducci, Erica N; Hill, Alison; Lewis, Mark G; Geleziunas, Romas; Robb, Merlin L; Michael, Nelson L; Barouch, Dan H.
Afiliação
  • Whitney JB; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA. jwhitne2@bidmc.harvard.edu.
  • Lim SY; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139, USA. jwhitne2@bidmc.harvard.edu.
  • Osuna CE; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
  • Kublin JL; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
  • Chen E; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
  • Yoon G; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
  • Liu PT; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
  • Abbink P; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
  • Borducci EN; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
  • Hill A; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
  • Lewis MG; Program for Evolutionary Dynamics, Harvard University, Cambridge, MA, 02138, USA.
  • Geleziunas R; Bioqual, Rockville, MD, 20852, USA.
  • Robb ML; Gilead Sciences, Foster City, CA, 94404, USA.
  • Michael NL; U.S. Military HIV Research Program, Henry Jackson Foundation, 6720 Rockledge Drive, Bethesda, MD, 20817, USA.
  • Barouch DH; Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD, 20910, USA.
Nat Commun ; 9(1): 5429, 2018 12 21.
Article em En | MEDLINE | ID: mdl-30575753
ABSTRACT
The precise time when the viral reservoir is seeded during acute HIV-1 infection remains unclear. We previously demonstrated that the viral reservoir was seeded by day 3 following SIVmac251 infection in rhesus monkeys. Here we report the impact of initiating ART on day 0 (6 h), 1, 2, or 3 following intrarectal SIVmac251 infection in 20 rhesus monkeys (N = 5/group). After 6 months of daily suppressive ART, antiretroviral drugs were discontinued, and viral rebound was monitored. 0% (0 of 5), 20% (1 of 5), 60% (3 of 5), and 100% (5 of 5) of animals that initiated ART on days 0 (6 h), 1, 2, or 3, respectively, showed viral rebound following ART discontinuation and correlated with integrated viral DNA in lymph node CD4+ T cells. These data demonstrate that the viral reservoir is seeded within the first few days of infection and that early ART initiation limits the viral reservoir.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome de Imunodeficiência Adquirida dos Símios / Antirretrovirais Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome de Imunodeficiência Adquirida dos Símios / Antirretrovirais Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article