Biodegradable-Polymer Versus Polymer-Free Drug-Eluting Stents for the Treatment of Coronary Artery Disease.
Cardiovasc Revasc Med
; 20(10): 865-870, 2019 10.
Article
em En
| MEDLINE
| ID: mdl-30578169
BACKGROUND/PURPOSE: Biodegradable-polymer (BP) and polymer-free (PF) drug eluting stents (DES) were developed to reduce the risk of delayed arterial healing observed with durable-polymer (DP) platforms. Although trials demonstrate BP-DES and PF-DES are non-inferior to DP-DES, there is limited data directly comparing these technologies. We performed a meta-analysis to assess the efficacy and safety of BP-DES versus PF-DES for the treatment of coronary artery disease. METHODS/MATERIALS: Electronic searches were performed identifying randomized trials comparing BP-DES with PF-DES. Co-primary efficacy endpoints were target vessel revascularization (TVR), target lesion revascularization (TLR) and angiographic in-stent late lumen loss (LLL). Co-secondary safety endpoints were all-cause death, myocardial infarction (MI) and stent thrombosis (ST). RESULTS: Of 208 studies, 5 met inclusion criteria including 1975 patients. At mean follow-up (14⯱â¯5â¯months), BP-DES were associated with significantly reduced rates of TVR (OR 0.58, 95%CI 0.37-0.92, pâ¯=â¯0.02), TLR (4.7% vs 9.5%) (OR 0.48, 95%CI 0.31-0.75, pâ¯=â¯0.001) and in-stent LLL (pooled mean difference -0.20â¯mm, 95%CI -0.24 to -0.16, pâ¯<â¯0.001). There was no difference in safety, including all-cause death (OR 1.24, 95%CI 0.68-2.28, pâ¯=â¯0.48), MI (OR 0.92, 95%CI 0.54-1.56, pâ¯=â¯0.75) or ST (OR 1.58, 95%CI 0.67-3.73, pâ¯=â¯0.30). CONCLUSIONS: These data suggests that BP-DES are more efficacious when compared with PF-DES for the treatment of CAD.
Palavras-chave
Texto completo:
1
Eixos temáticos:
Pesquisa_clinica
Base de dados:
MEDLINE
Assunto principal:
Polímeros
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Doença da Artéria Coronariana
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Implantes Absorvíveis
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Stents Farmacológicos
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Intervenção Coronária Percutânea
Tipo de estudo:
Clinical_trials
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Etiology_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article