Application of high-throughput, capillary-based Western analysis to modulated cleavage of the cellular prion protein.

Castle, Andrew R; Daude, Nathalie; Gilch, Sabine; Westaway, David

Castle, Andrew R; Daude, Nathalie; Gilch, Sabine; Westaway, David.

Afiliação

Castle AR; From the Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta T6G 2M8, Canada.
Daude N; Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2G3, Canada.
Gilch S; From the Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta T6G 2M8, Canada.
Westaway D; Department of Ecosystem and Public Health, Calgary Prion Research Unit, Faculty of Veterinary Medicine and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada, and.

J Biol Chem ; 294(8): 2642-2650, 2019 02 22.

Article em En | MEDLINE | ID: mdl-30578300

Assuntos

Western Blotting/métodos; Encéfalo/metabolismo; Células Epiteliais/metabolismo; Ensaios de Triagem em Larga Escala/métodos; Rim/metabolismo; Proteínas PrPC/metabolismo; Animais; Células Epiteliais/citologia; Rim/citologia; Camundongos; Camundongos Transgênicos; Proteólise; Coelhos

Palavras-chave

prion disease; neurodegeneration; proteolysis; high-throughput screening (HTS); glycoprotein; protein misfolding; capillary Western; PrPC; simple Western

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Western Blotting / Proteínas PrPC / Células Epiteliais / Ensaios de Triagem em Larga Escala / Rim Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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