Two new compounds from Streptomyces sp. HS-NF-813.
J Asian Nat Prod Res
; 22(3): 249-256, 2020 Mar.
Article
em En
| MEDLINE
| ID: mdl-30585506
ABSTRACT
Two new derivatives of cytotoxic substance BE-52211, designed as BE-52211D (1) and BE-52211E (2), were isolated from the fermentation broth of the strain Streptomyces sp. HS-NF-813. Their structures were determined by 1D and 2D NMR techniques, ESI-MS and comparison with data from the literature. The absolute stereochemistry of 1 was elucidated by NMR data of the Mosher ester derivatives. Compounds 1 and 2 showed moderate cytotoxic activity against three human tumor cell lines.
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Base de dados:
MEDLINE
Assunto principal:
Streptomyces
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article