The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers.
Int J Mol Sci
; 20(1)2018 Dec 30.
Article
em En
| MEDLINE
| ID: mdl-30598013
ABSTRACT
Microvascular endothelial cells are an essential part of many biological barriers, such as the bloodâ»brain barrier (BBB) and the endothelium of the arteries and veins. A reversible opening strategy to increase the permeability of drugs across the BBB could lead to improved therapies due to enhanced drug bioavailability. Vanilloids, such as capsaicin, are known to reversibly open tight junctions of epithelial and endothelial cells. In this study, we used several in vitro assays with the murine endothelial capillary brain cells (line cEND) as a BBB model to characterize the interaction between capsaicin and endothelial tight junctions.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Endotélio Vascular
/
Barreira Hematoencefálica
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Capsaicina
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Células Endoteliais
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article