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The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers.
Kaiser, Mathias; Burek, Malgorzata; Britz, Stefan; Lankamp, Frauke; Ketelhut, Steffi; Kemper, Björn; Förster, Carola; Gorzelanny, Christian; Goycoolea, Francisco M.
Afiliação
  • Kaiser M; Max Delbrück Center for Molecular Medicine, Robert-Rössle-Straße 10, 13125 Berlin, Germany. Mathias.Kaiser@mdc-berlin.de.
  • Burek M; Institute of Plant Biology and Biotechnology (IBBP), Westfälische Wilhelms-Universität Münster, Schlossgarten 3, 48149 Münster, Germany. Mathias.Kaiser@mdc-berlin.de.
  • Britz S; Deparment of Anaesthesia and Critical Care, University of Würzburg, Oberdürrbacher Straße 6, 97080 Würzburg, Germany. Burek_M@ukw.de.
  • Lankamp F; Institute of Plant Biology and Biotechnology (IBBP), Westfälische Wilhelms-Universität Münster, Schlossgarten 3, 48149 Münster, Germany. stefan.bulla@gmx.at.
  • Ketelhut S; Institute of Plant Biology and Biotechnology (IBBP), Westfälische Wilhelms-Universität Münster, Schlossgarten 3, 48149 Münster, Germany. f_lank01@uni-muenster.de.
  • Kemper B; Biomedical Technology Center of the Medical Faculty, Westfälische Wilhelms-Universität Münster Mendelstraße 17, 48149 Münster, Germany. ketelhut@uni-muenster.de.
  • Förster C; Biomedical Technology Center of the Medical Faculty, Westfälische Wilhelms-Universität Münster Mendelstraße 17, 48149 Münster, Germany. bkemper@uni-muenster.de.
  • Gorzelanny C; Deparment of Anaesthesia and Critical Care, University of Würzburg, Oberdürrbacher Straße 6, 97080 Würzburg, Germany. foerster_c@ukw.de.
  • Goycoolea FM; Department of Dermatology and Venerology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. c.gorzelanny@uke.de.
Int J Mol Sci ; 20(1)2018 Dec 30.
Article em En | MEDLINE | ID: mdl-30598013
ABSTRACT
Microvascular endothelial cells are an essential part of many biological barriers, such as the blood⁻brain barrier (BBB) and the endothelium of the arteries and veins. A reversible opening strategy to increase the permeability of drugs across the BBB could lead to improved therapies due to enhanced drug bioavailability. Vanilloids, such as capsaicin, are known to reversibly open tight junctions of epithelial and endothelial cells. In this study, we used several in vitro assays with the murine endothelial capillary brain cells (line cEND) as a BBB model to characterize the interaction between capsaicin and endothelial tight junctions.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Endotélio Vascular / Barreira Hematoencefálica / Capsaicina / Células Endoteliais Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Endotélio Vascular / Barreira Hematoencefálica / Capsaicina / Células Endoteliais Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article