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Methemoglobinemia as a biomarker of dapsone-induced mania severity.
Colle, Romain; Ait Tayeb, Abd El Kader; Mesdom, Pierre; de Menthon, Mathilde; Becquemont, Laurent; Verstuyft, Céline; David, Denis J; Lambotte, Olivier; Corruble, Emmanuelle.
Afiliação
  • Colle R; Service Hospitalo-Universitaire de Psychiatrie de Bicêtre, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-94275, France; INSERM UMR-1178, CESP, "Depression and Antidepressants" team, Faculté de Médecine Paris-Sud, Université Paris
  • Ait Tayeb AEK; Service Hospitalo-Universitaire de Psychiatrie de Bicêtre, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-94275, France; INSERM UMR-1178, CESP, "Depression and Antidepressants" team, Faculté de Médecine Paris-Sud, Université Paris
  • Mesdom P; INSERM UMR-1178, CESP, "Depression and Antidepressants" team, Faculté de Médecine Paris-Sud, Université Paris Sud, France.
  • de Menthon M; Service de Médecine Interne et Immunologie Clinique, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-94275, France.
  • Becquemont L; INSERM UMR-1178, CESP, "Depression and Antidepressants" team, Faculté de Médecine Paris-Sud, Université Paris Sud, France; Service de Génétique moléculaire, Pharmacogénétique et Hormonologie, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre, Le Kremlin Bic
  • Verstuyft C; INSERM UMR-1178, CESP, "Depression and Antidepressants" team, Faculté de Médecine Paris-Sud, Université Paris Sud, France; Service de Génétique moléculaire, Pharmacogénétique et Hormonologie, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre, Le Kremlin Bic
  • David DJ; INSERM UMR-1178, CESP, "Depression and Antidepressants" team, Faculté de Pharmacie de Chatenay-Malabry, Université Paris Sud, France.
  • Lambotte O; Service de Médecine Interne et Immunologie Clinique, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-94275, France.
  • Corruble E; Service Hospitalo-Universitaire de Psychiatrie de Bicêtre, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-94275, France; INSERM UMR-1178, CESP, "Depression and Antidepressants" team, Faculté de Médecine Paris-Sud, Université Paris
J Affect Disord ; 254: 122-123, 2019 07 01.
Article em En | MEDLINE | ID: mdl-30598189
ABSTRACT

BACKGROUND:

The underlying mechanism involved in dapsone-induced mania remains unknown.

METHODS:

We report the case of a 54-year-old man with a dapsone-induced mania.

RESULTS:

The maximum of manic symptoms was correlated with the maximum of methemoglobinemia and mania decreased concomitantly with the methemoglobinemia level.

LIMITATIONS:

This is a single case.

CONCLUSIONS:

This case shows that dapsone-induced mania severity is correlated with methemoglobinemia level, leading for the first time to the hypothesis of a physiopathological mechanism by which dapsone could induce mania.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Dapsona / Metemoglobinemia Limite: Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Dapsona / Metemoglobinemia Limite: Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article