Long-term Efficacy of Single-agent Vemurafenib for Pleomorphic Xanthoastrocytoma.
J Pediatr Hematol Oncol
; 42(2): 152-155, 2020 03.
Article
em En
| MEDLINE
| ID: mdl-30601402
ABSTRACT
Pleomorphic xanthoastrocytoma is a malignant brain tumor that has a good prognosis with complete resection but does not respond well to chemotherapy if there is residual tumor. BRAF V600E mutations are common in pleomorphic xanthoastrocytomas and provide an additional means for treatment when excision is not possible. Monotherapy with the BRAF V600E inhibitor vemurafenib has only been reported in a small number of cases and mostly in adults. We present the case of a 16-year-old male who responded to vemurafenib monotherapy initially and had an additional response to vemurafenib following progression after a brief time off the medication.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Astrocitoma
/
Neoplasias Encefálicas
/
Vemurafenib
/
Antineoplásicos
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article