The FGF-related oncogene, K-FGF, maps to human chromosome region 11q13, possibly near int-2.
Oncogene Res
; 3(3): 263-70, 1988.
Article
em En
| MEDLINE
| ID: mdl-3060803
ABSTRACT
The protein encoded in a novel human oncogene isolated by transfection of Kaposi's sarcoma DNA is a growth factor with significant homology to basic and acidic FGFs. The genomic structure of this oncogene (designated K-FGF), as originally isolated, carried DNA rearrangements upstream and downstream of the coding region. The normally discontinuous sequence upstream of the K-FGF coding region derived from the 3' end of the c-fms gene and thus originated from human chromosome 5. In order to determine the normal chromosomal location of the K-FGF gene and of the DNA sequences adjacent to its 3' end, we have correlated the presence of these sequences with retention of specific human chromosome regions in rodent-human somatic cell hybrids. These experiments mapped the K-FGF gene to human chromosome region 11q13----11q23, and in situ hybridization localized it more precisely to region 11q13 near int-2, which also belongs to the FGF family. The sequence downstream of the gene in transfectants and discontinuous with K-FGF in normal human DNA derives from chromosome region 12p12----12q13, possibly near the int-1 locus.
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Base de dados:
MEDLINE
Assunto principal:
Oncogenes
/
Sarcoma de Kaposi
/
Cromossomos Humanos Par 11
/
Família Multigênica
/
Fatores de Crescimento de Fibroblastos
Limite:
Humans
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article