Actin Post-translational Modifications: The Cinderella of Cytoskeletal Control.
Trends Biochem Sci
; 44(6): 502-516, 2019 06.
Article
em En
| MEDLINE
| ID: mdl-30611609
ABSTRACT
Actin is one of the most abundant proteins in eukaryotic cells and the main component of the microfilament system. It plays essential roles in numerous cellular activities, including muscle contraction, maintenance of cell integrity, and motility, as well as transcriptional regulation. Besides interacting with various actin-binding proteins (ABPs), proper actin function is regulated by post-translational modifications (PTMs), such as acetylation, arginylation, oxidation, and others. Here, we explain how actin PTMs can contribute to filament formation and stability, and may have additional actin regulatory functions, which potentially contribute to disease development.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Citoesqueleto
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Processamento de Proteína Pós-Traducional
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Actinas
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article