Endothelial stromelysin1 regulation by the forkhead box-O transcription factors is crucial in the exudative phase of acute lung injury.

Artham, Sandeep; Gao, Fei; Verma, Arti; Alwhaibi, Abdulrahman; Sabbineni, Harika; Hafez, Sherif; Ergul, Adviye; Somanath, Payaningal R

Artham, Sandeep; Gao, Fei; Verma, Arti; Alwhaibi, Abdulrahman; Sabbineni, Harika; Hafez, Sherif; Ergul, Adviye; Somanath, Payaningal R.

Afiliação

Artham S; Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA 30912, United States.
Gao F; Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA 30912, United States; Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Verma A; Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA 30912, United States.
Alwhaibi A; Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA 30912, United States.
Sabbineni H; Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA 30912, United States.
Hafez S; Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA 30912, United States; Department of Pharmaceutical Sciences, College of Pharmacy, Larkin University, Miami, FL 33169, United States.
Ergul A; Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA 30912, United States; Department of Physiology, Augusta University, Augusta, GA 30912, United States.
Somanath PR; Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA 30912, United States; Department of Medicine, Vascular Biology Center and Cancer Center, Augusta University, Augusta, GA 30912, United States. Electronic address: ssh

Pharmacol Res ; 141: 249-263, 2019 03.

Article em En | MEDLINE | ID: mdl-30611853

Assuntos

Lesão Pulmonar Aguda/metabolismo; Proteína Forkhead Box O1/metabolismo; Proteína Forkhead Box O3/metabolismo; Metaloproteinase 3 da Matriz/metabolismo; Proteínas Proto-Oncogênicas c-akt/genética; Lesão Pulmonar Aguda/induzido quimicamente; Lesão Pulmonar Aguda/patologia; Animais; Células Cultivadas; Células Endoteliais; Feminino; Proteína Forkhead Box O1/antagonistas & inibidores; Proteína Forkhead Box O1/genética; Proteína Forkhead Box O3/antagonistas & inibidores; Proteína Forkhead Box O3/genética; Humanos; Lipopolissacarídeos; Masculino; Camundongos Knockout; Quinolonas/farmacologia; RNA Interferente Pequeno/genética

Palavras-chave

ARDS; Akt1; Claudin5; FoxO; Lung injury; MMP3; Stromelysin1

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Metaloproteinase 3 da Matriz / Proteínas Proto-Oncogênicas c-akt / Lesão Pulmonar Aguda / Proteína Forkhead Box O3 / Proteína Forkhead Box O1 Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google