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Orbital apex venous cavernous malformation with optic neuropathy: treatment with multisession gamma knife radiosurgery.
Young, Stephanie Ming; Kim, Kyung Hwan; Kim, Yoon-Duck; Lang, Stephanie S; Park, Ji Woong; Woo, Kyung In; Lee, Jung-Il.
Afiliação
  • Young SM; Department of Ophthalmology, National University Hospital, Singapore, Singapore.
  • Kim KH; Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
  • Kim YD; Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea yoonduck.kim@samsung.com jilee.lee@samsung.com.
  • Lang SS; Clinical Audit, Singapore National Eye Centre, Singapore, Singapore.
  • Park JW; Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
  • Woo KI; Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
  • Lee JI; Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea yoonduck.kim@samsung.com jilee.lee@samsung.com.
Br J Ophthalmol ; 103(10): 1453-1459, 2019 10.
Article em En | MEDLINE | ID: mdl-30612095
PURPOSE: To evaluate the efficacy and safety of multisession gamma knife radiosurgery (GKRS) for orbital apex venous cavernous malformation causing optic neuropathy. METHODS: Retrospective cohort study in a single tertiary institution from January 2007 to December 2016 on patients who underwent multisession GKRS for orbital apex venous cavernous malformations causing optic neuropathy. RESULTS: There were 12 patients included in our study. The mean age was 40.2±14.5 years, and men comprised 66.7% (n=8). Decrease in visual acuity (83.3%) was the most common symptom at presentation. The mean clinical follow-up was 28.5 months. Ten (83.3%) of the 12 patients had improvement in best corrected visual acuity. Of the 10 patients with pre-existing relative afferent pupillary defect (RAPD), 6 (60%) had complete resolution of RAPD. Of the 12 patients with visual field defect, 7 (58.3%) had complete resolution, 3 (25%) had partial improvement, while 2 (16.7%) remained unchanged due to optic atrophy from long-standing compressive optic neuropathy. Mean proptosis reduced from 2.3±1.7 mm pre-GKRS to 0.5±1.3 mm post-GKRS (p=0.005). Tumour shrinkage was observed in all patients. The mean tumour volume at the time of GKRS was 3104 mm3 (range 221-8500 mm3), which reduced to 658 mm3 (range 120-3350 mm3) at last follow-up. None of the patients experienced GKRS-related ocular morbidity during the follow-up period. CONCLUSION: Multisession GKRS has shown to be an effective and safe option for the treatment of orbital apex venous cavernous malformations causing optic neuropathy, with significant improvement in ophthalmic outcomes and reduction in tumour volume.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Orbitárias / Doenças do Nervo Óptico / Radiocirurgia / Hemangioma Cavernoso Tipo de estudo: Observational_studies Limite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Orbitárias / Doenças do Nervo Óptico / Radiocirurgia / Hemangioma Cavernoso Tipo de estudo: Observational_studies Limite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article