Cobalt-Catalyzed Intermolecular [2+2] Cycloaddition between Alkynes and Allenes.
Angew Chem Int Ed Engl
; 58(8): 2500-2504, 2019 Feb 18.
Article
em En
| MEDLINE
| ID: mdl-30614605
An intermolecular [2+2] cycloaddition reaction between an alkyne and an allene is reported. In the presence of a cobalt(I)/diphosphine catalyst, a near equimolar mixture of the alkyne and allene is converted into a 3-alkylidenecyclobutene derivative in good yield with high regioselectivity. The reaction tolerates a variety of internal alkynes and mono- or disubstituted allenes bearing various functional groups. The reaction is proposed to involve regioselective oxidative cyclization of the alkyne and allene to form a 4-alkylidenecobaltacyclopentene intermediate, with subsequent C-C reductive elimination.
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MEDLINE
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En
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2019
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Article