[Mesenchymal stem cells and regenerative medicine: future perspectives in osteoarthritis]. / Cellules souches mésenchymateuses et médecine régénératrice - Quel avenir pour l'arthrose ?
Med Sci (Paris)
; 34(12): 1092-1099, 2018 Dec.
Article
em Fr
| MEDLINE
| ID: mdl-30623767
ABSTRACT
Mesenchymal stromal or stem cells (MSCs) are multipotent adult cells that can be isolated from a variety of adult or neonatal tissues, such as bone marrow, fat tissue, placenta or umbilical cord. A therapy based on MSCs can be justified in osteoarthritis (OA) thanks to their differentiation abilities but mostly, to their paracrine and immunosuppressive properties. Possible therapeutic strategies therefore rely on the articular injection of MSCs suspensions for trophic activity or the implantation of MSCs combined with biodegradable materials for tissue engineering applications. Depending on the mode of administration and behavior after implantation, they can decrease local inflammation, prevent chondrocyte hypertrophy and apoptosis as well as differentiate into cartilage-forming chondrocytes. In this review, we summarize pathophysiological and mechanistic data and discuss perspectives confirming the interest of MSCs as a potential therapeutic strategy in OA.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Osteoartrite
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Engenharia Tecidual
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Transplante de Células-Tronco Mesenquimais
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Medicina Regenerativa
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Células-Tronco Mesenquimais
Limite:
Animals
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Humans
Idioma:
Fr
Ano de publicação:
2018
Tipo de documento:
Article