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Post-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates.
Brannan, Jennifer M; He, Shihua; Howell, Katie A; Prugar, Laura I; Zhu, Wenjun; Vu, Hong; Shulenin, Sergey; Kailasan, Shweta; Raina, Henna; Wong, Gary; Rahim, Md Niaz; Banadyga, Logan; Tierney, Kevin; Zhao, Xuelian; Li, Yuxing; Holtsberg, Frederick W; Dye, John M; Qiu, Xiangguo; Aman, M Javad.
Afiliação
  • Brannan JM; US Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Frederick, MD, 21702, USA.
  • He S; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, MB, R3E 3R2, Canada.
  • Howell KA; Integrated BioTherapeutics, Inc., 4 Research Court, Suite 300, Rockville, MD, 20850, USA.
  • Prugar LI; US Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Frederick, MD, 21702, USA.
  • Zhu W; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, MB, R3E 3R2, Canada.
  • Vu H; Integrated BioTherapeutics, Inc., 4 Research Court, Suite 300, Rockville, MD, 20850, USA.
  • Shulenin S; Integrated BioTherapeutics, Inc., 4 Research Court, Suite 300, Rockville, MD, 20850, USA.
  • Kailasan S; Integrated BioTherapeutics, Inc., 4 Research Court, Suite 300, Rockville, MD, 20850, USA.
  • Raina H; Integrated BioTherapeutics, Inc., 4 Research Court, Suite 300, Rockville, MD, 20850, USA.
  • Wong G; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, MB, R3E 3R2, Canada.
  • Rahim MN; Department of Medical Microbiology, University of Manitoba, 745 Bannatyne Avenue, Winnipeg, MB, R3E 0J9, Canada.
  • Banadyga L; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, MB, R3E 3R2, Canada.
  • Tierney K; Department of Medical Microbiology, University of Manitoba, 745 Bannatyne Avenue, Winnipeg, MB, R3E 0J9, Canada.
  • Zhao X; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, MB, R3E 3R2, Canada.
  • Li Y; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, MB, R3E 3R2, Canada.
  • Holtsberg FW; Department of Microbiology and Immunology, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD, 21201, USA.
  • Dye JM; Department of Microbiology and Immunology, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD, 21201, USA.
  • Qiu X; Institute for Bioscience and Biotechnology Research, University of Maryland, 9600 Gudelsky Drive, Rockville, MD, 20850, USA.
  • Aman MJ; Integrated BioTherapeutics, Inc., 4 Research Court, Suite 300, Rockville, MD, 20850, USA.
Nat Commun ; 10(1): 105, 2019 01 10.
Article em En | MEDLINE | ID: mdl-30631063
ABSTRACT
The 2013-2016 Ebola virus (EBOV) disease epidemic demonstrated the grave consequences of filovirus epidemics in the absence of effective therapeutics. Besides EBOV, two additional ebolaviruses, Sudan (SUDV) and Bundibugyo (BDBV) viruses, as well as multiple variants of Marburg virus (MARV), have also caused high fatality epidemics. Current experimental EBOV monoclonal antibodies (mAbs) are ineffective against SUDV, BDBV, or MARV. Here, we report that a cocktail of two broadly neutralizing ebolavirus mAbs, FVM04 and CA45, protects nonhuman primates (NHPs) against EBOV and SUDV infection when delivered four days post infection. This cocktail when supplemented by the anti-MARV mAb MR191 exhibited 100% efficacy in MARV-infected NHPs. These findings provide a solid foundation for clinical development of broadly protective immunotherapeutics for use in future filovirus epidemics.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças dos Primatas / Infecções por Filoviridae / Ebolavirus / Anticorpos Neutralizantes / Marburgvirus / Anticorpos Monoclonais Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças dos Primatas / Infecções por Filoviridae / Ebolavirus / Anticorpos Neutralizantes / Marburgvirus / Anticorpos Monoclonais Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article