CDK6 coordinates JAK2 V617F mutant MPN via NF-κB and apoptotic networks.
Blood
; 133(15): 1677-1690, 2019 04 11.
Article
em En
| MEDLINE
| ID: mdl-30635286
ABSTRACT
Over 80% of patients with myeloproliferative neoplasms (MPNs) harbor the acquired somatic JAK2 V617F mutation. JAK inhibition is not curative and fails to induce a persistent response in most patients, illustrating the need for the development of novel therapeutic approaches. We describe a critical role for CDK6 in MPN evolution. The absence of Cdk6 ameliorates clinical symptoms and prolongs survival. The CDK6 protein interferes with 3 hallmarks of disease besides regulating malignant stem cell quiescence, it promotes nuclear factor κB (NF-κB) signaling and contributes to cytokine production while inhibiting apoptosis. The effects are not mirrored by palbociclib, showing that the functions of CDK6 in MPN pathogenesis are largely kinase independent. Our findings thus provide a rationale for targeting CDK6 in MPN.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
NF-kappa B
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Apoptose
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Quinase 6 Dependente de Ciclina
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Janus Quinase 2
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Mutação
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Transtornos Mieloproliferativos
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article