Concise review: The challenges and opportunities of employing mesenchymal stromal cells in the treatment of acute pancreatitis.
Biotechnol Adv
; 42: 107338, 2020.
Article
em En
| MEDLINE
| ID: mdl-30639517
ABSTRACT
To date only small animal models have been employed to assess the effect of mesenchymal stromal cell (MSC) therapy on acute pancreatitis (AP), the most common cause of hospitalization for gastrointestinal diseases worldwide. We outline the challenges inherent in the small animal models of AP. We also point to specific benefits afforded by the adoption of larger animal models. The potential for MSC therapeutics in the treatment of AP was recognized over a decade ago. With sharper focus on the form of AP and development of new MSC delivery routes in larger animals, we believe the challenge can be engaged.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pancreatite
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Transplante de Células-Tronco Mesenquimais
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Células-Tronco Mesenquimais
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article