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Bilingualism in Primary Progressive Aphasia: A Retrospective Study on Clinical and Language Characteristics.
Costa, Ana S; Jokel, Regina; Villarejo, Alberto; Llamas-Velasco, Sara; Domoto-Reilley, Kimiko; Wojtala, Jennifer; Reetz, Kathrin; Machado, Álvaro.
Afiliação
  • Costa AS; Neurocognition Unit, Department of Neurology, Hospital de Braga, Sete Fontes-São Victor, Braga, Portugal.
  • Jokel R; Department of Neurology, RWTH Aachen University, Pauwelsstr, Aachen.
  • Villarejo A; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH, Jülich and RWTH Aachen University, Aachen, Germany.
  • Llamas-Velasco S; Rotman Research Institute, 3560 Bathurst Street, North York, Ontario.
  • Domoto-Reilley K; University of Toronto, 500 University Avenue, Toronto, Canada.
  • Wojtala J; Department of Neurology, Hospital 12 de Octubre.
  • Reetz K; Imas12. CIBERNED. Universidad Complutense de Madrid, Avda. de Córdoba, Madrid, Spain.
  • Machado Á; Department of Neurology, Hospital 12 de Octubre.
Alzheimer Dis Assoc Disord ; 33(1): 47-53, 2019.
Article em En | MEDLINE | ID: mdl-30640254
ABSTRACT

BACKGROUND:

Primary progressive aphasia (PPA) is a neurodegenerative disorder characterized by progressive deterioration of language. Being rare, reports of PPA in multilingual individuals are scarce, despite more than half of the world population being multilingual.

METHODS:

We describe clinical characteristics of 33 bilingual patients with PPA, including symptom presentation and language deficits pattern in their first (L1) and second language (L2), through a systematic literature review and new cases retrospectively identified in 5 countries.

RESULTS:

In total, 14 patients presented with nonfluent/agrammatic variant, 6 with semantic variant, and 13 with logopenic variant, with a median symptom onset of 2 years. Word-finding difficulties was the first symptom in 65% of all cases, initially noticed in L2, and not always the dominant language. Our group had 22 different languages as L1, and 9 as L2. At the whole-group level there was a tendency for parallel impairment in both languages, in line with the shared bilingual neural substrate hypothesis, but each PPA variant showed some heterogeneity.

DISCUSSION:

Each PPA variant showed heterogeneity, showing the need for comprehensive language and cognitive assessment across languages, as well as further clarification on the role of language mediators.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Afasia Primária Progressiva / Multilinguismo / Idioma Tipo de estudo: Observational_studies / Prognostic_studies Limite: Aged / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Afasia Primária Progressiva / Multilinguismo / Idioma Tipo de estudo: Observational_studies / Prognostic_studies Limite: Aged / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article