Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study.
J Epidemiol
; 29(12): 478-486, 2019 Dec 05.
Article
em En
| MEDLINE
| ID: mdl-30643099
ABSTRACT
BACKGROUND:
Metal exposures could possibly affect allergic responses in pregnant women, although no studies have yet shown a clear relationship between the two, and such exposures might also affect the development of allergic diseases in children.METHODS:
We investigated the relationship between metal concentrations in whole blood and immunoglobulin E (IgE; total and specific) in 14,408 pregnant women who participated in the Japan Environment and Children's Study. The subjects submitted self-administered questionnaires, and blood samples were collected from them twice, specifically, during the first trimester and again during the second/third trimester. Concentrations of the metals Cd, Pb, Hg, Se, and Mn, as well as serum total and allergen-specific IgEs for egg white, house dust-mites (HDM), Japanese cedar pollen (JCP), animal dander, and moth, were measured. Allergen-specific IgE(s) were divided based on concentrations <0.35 or ≥0.35 UA/mL, and the metal levels were divided into quartiles.RESULTS:
Multivariable logistic regression analysis showed that there was a significant negative correlation between HDM- and animal dander-specific IgEs and Hg and Mn concentrations. Conversely, there was a significant positive relationship between JCP-specific IgE and Hg and Se concentrations.CONCLUSIONS:
Metal exposures may be related to both increases and decreases in allergen-specific IgEs in pregnant women.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina E
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Metais
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Pregnancy
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article