Evaluation of 1,2,3-Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX-770 and VX-809.

Doiron, Jake E; Le, Christina A; Ody, Britton K; Brace, Jonathon B; Post, Savannah J; Thacker, Nathan L; Hill, Harrison M; Breton, Gary W; Mulder, Matthew J; Chang, Sichen; Bridges, Thomas M; Tang, Liping; Wang, Wei; Rowe, Steven M; Aller, Stephen G; Turlington, Mark

Doiron, Jake E; Le, Christina A; Ody, Britton K; Brace, Jonathon B; Post, Savannah J; Thacker, Nathan L; Hill, Harrison M; Breton, Gary W; Mulder, Matthew J; Chang, Sichen; Bridges, Thomas M; Tang, Liping; Wang, Wei; Rowe, Steven M; Aller, Stephen G; Turlington, Mark.

Afiliação

Doiron JE; Department of Chemistry and Biochemistry, Berry College, Mount Berry, Georgia, 30165, USA.
Le CA; Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama, 35205, USA.
Ody BK; Department of Chemistry and Biochemistry, Berry College, Mount Berry, Georgia, 30165, USA.
Brace JB; Department of Chemistry and Biochemistry, Berry College, Mount Berry, Georgia, 30165, USA.
Post SJ; Department of Chemistry and Biochemistry, Berry College, Mount Berry, Georgia, 30165, USA.
Thacker NL; Department of Chemistry and Biochemistry, Berry College, Mount Berry, Georgia, 30165, USA.
Hill HM; Department of Chemistry and Biochemistry, Berry College, Mount Berry, Georgia, 30165, USA.
Breton GW; Department of Chemistry and Biochemistry, Berry College, Mount Berry, Georgia, 30165, USA.
Mulder MJ; Vanderbilt Center for Neuroscience Drug Discovery, Nashville, Tennessee, 37232, USA.
Chang S; Vanderbilt Center for Neuroscience Drug Discovery, Nashville, Tennessee, 37232, USA.
Bridges TM; Vanderbilt Center for Neuroscience Drug Discovery, Nashville, Tennessee, 37232, USA.
Tang L; Departments of Medicine and Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, 35205, USA.
Wang W; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, 35205, USA.
Rowe SM; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, 35205, USA.
Aller SG; Department of Cell, Development, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, 35205, USA.
Turlington M; Departments of Medicine and Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, 35205, USA.