Resistin: A reappraisal.
Mech Ageing Dev
; 178: 46-63, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30650338
ABSTRACT
From a biological point of view, aging can be considered a progressive inability of an organism to react to stress, maintain homeostasis, and survive unfavourable changes during post-maturational life. The expression of several adipokines changes during aging and for some changes, a role in the onset of chronic disease and frailty has been proposed. Among adipokines, resistin was shown in recent studies to play a key role in aging. Resistin is a small secreted protein that regulates glucose metabolism in mammalians. High resistin levels induce insulin resistance and exert proinflammatory effects. Consistently, resistin has been shown to play a pivotal role in various metabolic, inflammatory, and autoimmune diseases. Herein, the role of resistin as a molecular link between aging and age-related conditions was reviewed and the clinical implications of this knowledge discussed.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Resistina
Tipo de estudo:
Diagnostic_studies
Limite:
Aged
/
Animals
/
Humans
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article