Fermentation Revisited: How Do Microorganisms Survive Under Energy-Limited Conditions?
Trends Biochem Sci
; 44(5): 391-400, 2019 05.
Article
em En
| MEDLINE
| ID: mdl-30655166
ABSTRACT
During fermentation FOF1 hydrolyzes ATP, coupling proton transport to proton-motive force (pmf) generation. Despite that, pmf generated by ATP hydrolysis does not satisfy the energy budget of a fermenting cell. However, pmf can also be generated by extrusion of weak organic acids such as lactate and by hydrogen cycling catalyzed by hydrogenases (Hyds). Here we highlight recent advances in our understanding of how the transport of weak organic acids and enzymes contributes to pmf generation during fermentation. The potential impact of these processes on metabolism and energy conservation during microbial fermentation have been overlooked and they not only expand on Mitchell's chemiosmotic theory but also are of relevance to the fields of microbial biochemistry and human and animal health.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bactérias
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Trifosfato de Adenosina
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Metabolismo Energético
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Fermentação
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Hidrogenase
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article