FAK inhibition reduces metastasis of &#945;4 integrin-expressing melanoma to lymph nodes by targeting lymphatic VCAM-1 expression.

Jeong, Kyuho; Murphy, James M; Rodriguez, Yelitza A R; Kim, Jun-Sub; Ahn, Eun-Young Erin; Lim, Ssang-Taek Steve

FAK inhibition reduces metastasis of α4 integrin-expressing melanoma to lymph nodes by targeting lymphatic VCAM-1 expression.

Jeong, Kyuho; Murphy, James M; Rodriguez, Yelitza A R; Kim, Jun-Sub; Ahn, Eun-Young Erin; Lim, Ssang-Taek Steve.

Afiliação

Jeong K; Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, AL, 36688, United States.
Murphy JM; Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, AL, 36688, United States.
Rodriguez YAR; Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, AL, 36688, United States.
Kim JS; Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, AL, 36688, United States; Department of Biotechnology, Korea National University of Transportation, Chungbuk, 27909, Republic of Korea.
Ahn EE; Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, AL, 36688, United States; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36604, United States.
Lim SS; Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, AL, 36688, United States. Electronic address: stlim@southalabama.edu.

Biochem Biophys Res Commun ; 509(4): 1034-1040, 2019 02 19.

Article em En | MEDLINE | ID: mdl-30660359

Assuntos

Proteína-Tirosina Quinases de Adesão Focal/antagonistas & inibidores; Integrina alfa4/metabolismo; Linfonodos/patologia; Melanoma/patologia; Metástase Neoplásica/prevenção & controle; Molécula 1 de Adesão de Célula Vascular/antagonistas & inibidores; Animais; Linhagem Celular; Humanos; Melanoma/química; Melanoma Experimental; Camundongos; Inibidores de Proteínas Quinases/farmacologia; Inibidores de Proteínas Quinases/uso terapêutico; Molécula 1 de Adesão de Célula Vascular/metabolismo

Palavras-chave

FAK; Lymph node; Melanoma; Metastasis; VCAM-1; α4 integrin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Molécula 1 de Adesão de Célula Vascular / Integrina alfa4 / Proteína-Tirosina Quinases de Adesão Focal / Linfonodos / Melanoma / Metástase Neoplásica Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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