Shikonin induces an antitumor effect on murine mammary cancer via p38dependent apoptosis.
Oncol Rep
; 41(3): 2020-2026, 2019 Mar.
Article
em En
| MEDLINE
| ID: mdl-30664166
ABSTRACT
Breast cancer is the most common malignancy in women. Apoptosis is important for tumor suppression and may delay cancer progression. It was found that shikonin induced apoptosis in 4T1 murine mammary cancer cells and MDAMB231 human breast cancer cells in vitro. Total p38 and cJun Nterminal kinase (JNK) levels were maintained in 4T1 cells, and p38 phosphorylation, but not JNK phosphorylation, was significantly increased. Caspase3/7 activity was detected, which suggested that the p38 pathway, but not the JNK signaling pathway, induced apoptosis in 4T1 cells. The antitumor effects of shikonin on orthotopic mouse models were also examined. On day 7 after inoculation of 4T1 cells into mice, tumor volumes in the shikonintreated and the control groups began to differ. On day 13, tumors were weighed, and shikonin was revealed to suppress tumor growth in the orthotopic 4T1 model in vivo. In conclusion, shikonin is a potential antitumor drug for breast cancer.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Naftoquinonas
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Apoptose
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Proteínas Quinases p38 Ativadas por Mitógeno
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Neoplasias Mamárias Experimentais
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Antineoplásicos
Limite:
Animals
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Female
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Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article