Reimagining the kidney biopsy in the era of diagnostic biomarkers of glomerular disease.
Kidney Int
; 95(2): 265-267, 2019 02.
Article
em En
| MEDLINE
| ID: mdl-30665567
ABSTRACT
Anti-phospholipase A2 receptor (PLA2R) antibody is a specific biomarker for primary membranous nephropathy (MN). Testing positive for anti-PLA2R has been postulated to establish a diagnosis of MN in the absence of a kidney biopsy. Bobart et al. tested this hypothesis and concluded that anti-PLA2R positivity is sufficient to diagnose primary MN and initiate treatment in a subset of patients with nephropathy. This biomarker, however, does not render the kidney biopsy obsolete, but encourages the application of molecular analyses to renal pathology to keep the biopsy relevant.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Glomerulonefrite Membranosa
/
Receptores da Fosfolipase A2
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article