Epitaxial Crystallization of Insulin on an Ordered 2D Polymer Template.
Chemistry
; 25(15): 3756-3760, 2019 Mar 12.
Article
em En
| MEDLINE
| ID: mdl-30667553
ABSTRACT
Two-dimensional polymers (2DP) are a new class of materials that consist of a monolayer of ordered molecular building blocks, which have been covalently linked. One of these monomers was self-assembled on a flat muscovite mica scaffold and subsequently the organic layer was polymerized. The resulting flat and stable 2DP layer was used as a template for protein crystallization. Crystals of insulin were epitaxially grown on the template, whereas insulin crystals grown on clean muscovite mica had a random orientation. The template was selective, considering that no epitaxially ordered crystals formed of hen egg white lysozyme, bovine serum albumin, or talin.
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MEDLINE
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En
Ano de publicação:
2019
Tipo de documento:
Article