Gene-function studies in systemic lupus erythematosus.
Curr Opin Rheumatol
; 31(2): 185-192, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30672908
ABSTRACT
PURPOSE OF REVIEW The aim of this review is to discuss recent developments in our understanding of how systemic lupus erythematosus (SLE)-associated genes contribute to autoimmunity. RECENT FINDINGS:
Gene-function studies have revealed mechanisms through which SLE-associated alleles of IFIH1, TNFAIP3, IRF5, and PRDM1 likely contribute to the development of autoimmunity. Novel research has identified Mac-1 (encoded by ITGAM), CaMK4, and iRhom2 as plausible therapeutic targets in lupus nephritis.SUMMARY:
The work discussed in this review has broad implications for our understanding of the pathogenesis of SLE and for the development of novel therapeutic strategies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA
/
Terapia Genética
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Regulação da Expressão Gênica
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Predisposição Genética para Doença
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Antígeno CD11b
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Lúpus Eritematoso Sistêmico
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article