Baicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF-&#954;B signaling pathway.

Jin, Xin; Liu, Ming-Yan; Zhang, Dong-Fang; Zhong, Xin; Du, Ke; Qian, Ping; Yao, Wei-Fan; Gao, Hua; Wei, Min-Jie

Baicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF-κB signaling pathway.

Jin, Xin; Liu, Ming-Yan; Zhang, Dong-Fang; Zhong, Xin; Du, Ke; Qian, Ping; Yao, Wei-Fan; Gao, Hua; Wei, Min-Jie.

Afiliação

Jin X; Department of Pharmacognosy, School of Pharmacy, China Medical University, Shenyang, China.
Liu MY; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.
Zhang DF; Department of Pharmacognosy, School of Pharmacy, China Medical University, Shenyang, China.
Zhong X; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.
Du K; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.
Qian P; Department of Pharmacognosy, School of Pharmacy, China Medical University, Shenyang, China.
Yao WF; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.
Gao H; Division of Pharmacology Laboratory, National Institutes for Food and Drug Control, Beijing, China.
Wei MJ; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.

CNS Neurosci Ther ; 25(5): 575-590, 2019 05.

Article em En | MEDLINE | ID: mdl-30676698

Assuntos

Anti-Inflamatórios não Esteroides/farmacologia; Disfunção Cognitiva/tratamento farmacológico; Flavonoides/farmacologia; Microglia/efeitos dos fármacos; Neurônios/efeitos dos fármacos; Nootrópicos/farmacologia; Animais; Linhagem Celular; Disfunção Cognitiva/metabolismo; Humanos; Inflamassomos/metabolismo; Inflamação/tratamento farmacológico; Inflamação/metabolismo; Camundongos; Microglia/metabolismo; NF-kappa B/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Neurônios/metabolismo; Fármacos Neuroprotetores/farmacologia; Distribuição Aleatória; Transdução de Sinais/efeitos dos fármacos; Receptor 4 Toll-Like/metabolismo

Palavras-chave

Alzheimer's disease; baicalin; cognitive impairment; neuroinflammation; neuronal protection

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Flavonoides / Anti-Inflamatórios não Esteroides / Microglia / Nootrópicos / Disfunção Cognitiva / Neurônios Tipo de estudo: Clinical_trials Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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