CENP-A Ubiquitylation Contributes to Maintaining the Chromosomal Location of the Centromere.
Molecules
; 24(3)2019 Jan 22.
Article
em En
| MEDLINE
| ID: mdl-30678315
ABSTRACT
The centromere plays an essential role in accurate chromosome segregation, and the chromosomal location of the centromere is determined by the presence of a histone H3 variant, centromere protein A (CENP-A), in centromeric nucleosomes. However, the precise mechanisms of deposition, maintenance, and inheritance of CENP-A at centromeres are unclear. We have reported that CENP-A deposition requires ubiquitylation of CENP-A lysine 124 mediated by the E3 ligase activity of Cullin 4A (CUL4A)-RING-box protein 1 (RBX1)-COP9 signalsome complex subunit 8 (COPS8). We have proposed a model of inheritance for CENP-A ubiquitylation, through dimerization between rounds of cell divisions, that maintains the position of centromeres.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Centrômero
/
Proteína Centromérica A
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article