Synthesis and biological evaluation of pyrazole linked benzothiazole-ß-naphthol derivatives as topoisomerase I inhibitors with DNA binding ability.

Nagaraju, Burri; Kovvuri, Jeshma; Kumar, C Ganesh; Routhu, Sunitha Rani; Shareef, Md Adil; Kadagathur, Manasa; Adiyala, Praveen Reddy; Alavala, Sateesh; Nagesh, Narayana; Kamal, Ahmed

Nagaraju, Burri; Kovvuri, Jeshma; Kumar, C Ganesh; Routhu, Sunitha Rani; Shareef, Md Adil; Kadagathur, Manasa; Adiyala, Praveen Reddy; Alavala, Sateesh; Nagesh, Narayana; Kamal, Ahmed.

Afiliação

Nagaraju B; Medicinal Chemistry and Biotechnology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, Telangana, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi 110025, India.
Kovvuri J; Medicinal Chemistry and Biotechnology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, Telangana, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi 110025, India.
Kumar CG; Medicinal Chemistry and Biotechnology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, Telangana, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi 110025, India. Electronic address: cgkumar.iict@gov.in.
Routhu SR; Medicinal Chemistry and Biotechnology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, Telangana, India.
Shareef MA; Medicinal Chemistry and Biotechnology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, Telangana, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi 110025, India.
Kadagathur M; Medicinal Chemistry and Biotechnology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, Telangana, India.
Adiyala PR; Medicinal Chemistry and Biotechnology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, Telangana, India.
Alavala S; Medicinal Chemistry and Biotechnology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, Telangana, India.
Nagesh N; CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500007, Telangana, India. Electronic address: nagesh@ccmb.res.in.
Kamal A; Medicinal Chemistry and Biotechnology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, Telangana, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi 110025, India; School of Pharmaceutical Education and Research, (SPER) Jamia Hamdard, New Delhi 110062, I

Bioorg Med Chem ; 27(5): 708-720, 2019 03 01.

Article em En | MEDLINE | ID: mdl-30679134

Assuntos

Benzotiazóis/farmacologia; Naftóis/farmacologia; Pirazóis/farmacologia; Inibidores da Topoisomerase I/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/metabolismo; Antineoplásicos/farmacologia; Benzotiazóis/síntese química; Benzotiazóis/metabolismo; Bisbenzimidazol/farmacologia; Linhagem Celular Tumoral; DNA/química; DNA/metabolismo; Doxorrubicina/farmacologia; Ensaios de Seleção de Medicamentos Antitumorais; Pontos de Checagem da Fase G2 do Ciclo Celular/efeitos dos fármacos; Humanos; Substâncias Intercalantes/síntese química; Substâncias Intercalantes/metabolismo; Substâncias Intercalantes/farmacologia; Simulação de Acoplamento Molecular; Naftóis/síntese química; Naftóis/metabolismo; Pirazóis/síntese química; Pirazóis/metabolismo; Inibidores da Topoisomerase I/síntese química; Inibidores da Topoisomerase I/metabolismo; Viscosidade

Palavras-chave

Anticancer; Benzothiazole; Betanaphthol; DNA binding; Pyrazole; Topoisomerase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Benzotiazóis / Inibidores da Topoisomerase I / Naftóis Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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