Down-regulation of Cdk1 activity in G1 coordinates the G1/S gene expression programme with genome replication.
Curr Genet
; 65(3): 685-690, 2019 Jun.
Article
em En
| MEDLINE
| ID: mdl-30680437
Cell division is regulated by cyclin-dependent kinases (Cdks) and requires the periodic activation and inactivation of transcription factors that generate waves of gene expression in different cell-cycle phases. In fission yeast, the MCB-binding transcription factor (MBF) is activated at the end of G1 and regulates the expression of a set of genes that encode for proteins involved in the G1/S transition and DNA replication. Here, we review the importance of controlling MBF by Cdk activity at the onset of S phase. Furthermore, we emphasize that MBF regulation by Cdk is particularly critical under conditions in which G1 is extended, such as in nitrogen-poor environments, where down-regulation of Cdk activity in G1 is crucial to generate a proper wave of MBF-dependent transcription at the end of G1, which is critical to promote a successful S phase.
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MEDLINE
Assunto principal:
Schizosaccharomyces
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Regulação Fúngica da Expressão Gênica
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Fase G1
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Proteína Quinase CDC2
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Fase S
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Genoma Fúngico
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Replicação do DNA
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article