Metastatic Prostate Cancer: Effects of Genetic Testing on Care.
Clin J Oncol Nurs
; 23(1): 32-35, 2019 02 01.
Article
em En
| MEDLINE
| ID: mdl-30681994
ABSTRACT
The National Comprehensive Cancer Network now recommends BRCA1/2 genetic testing in men with metastatic prostate cancer. The purpose of this article is to provide a review of principles of genetic testing in prostate cancer and highlight the significance of clinical genetic testing of BRCA1/2 and other genes (CHEK2, HOXB13, PALB2), including Lynch syndrome genes (MLH1, MSH2, MSH6, and PMS2) in men with metastatic prostate cancer. The potential impact of genetic testing on systemic treatments and the significance of the pathogenic results for at-risk family members is discussed.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
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Neoplasias Colorretais Hereditárias sem Polipose
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Proteína BRCA1
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Metástase Neoplásica
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Aged
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Aged80
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article