TDP-43 proteinopathy in aging: Associations with risk-associated gene variants and with brain parenchymal thyroid hormone levels.

Nelson, Peter T; Gal, Zsombor; Wang, Wang-Xia; Niedowicz, Dana M; Artiushin, Sergey C; Wycoff, Samuel; Wei, Angela; Jicha, Gregory A; Fardo, David W

Nelson, Peter T; Gal, Zsombor; Wang, Wang-Xia; Niedowicz, Dana M; Artiushin, Sergey C; Wycoff, Samuel; Wei, Angela; Jicha, Gregory A; Fardo, David W.

Afiliação

Nelson PT; Department of Pathology, Division of Neuropathology, University of Kentucky, Lexington, KY, USA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA. Electronic address: pnels2@email.uky.edu.
Gal Z; Department of Pathology, Division of Neuropathology, University of Kentucky, Lexington, KY, USA.
Wang WX; Department of Pathology, Division of Neuropathology, University of Kentucky, Lexington, KY, USA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA.
Niedowicz DM; Department of Pathology, Division of Neuropathology, University of Kentucky, Lexington, KY, USA.
Artiushin SC; Department of Pathology, Division of Neuropathology, University of Kentucky, Lexington, KY, USA.
Wycoff S; Department of Pathology, Division of Neuropathology, University of Kentucky, Lexington, KY, USA.
Wei A; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA.
Jicha GA; Department of Neurology, University of Kentucky, Lexington, KY, USA.
Fardo DW; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Biostatistics, University of Kentucky, Lexington, KY, USA.

Neurobiol Dis ; 125: 67-76, 2019 05.

Article em En | MEDLINE | ID: mdl-30682540

Assuntos

Encéfalo/patologia; Proteinopatias TDP-43/genética; Tiroxina; Tri-Iodotironina; Idoso; Idoso de 80 Anos ou mais; Envelhecimento; Encéfalo/metabolismo; Feminino; Predisposição Genética para Doença; Humanos; Masculino; Pessoa de Meia-Idade; Transportadores de Ânions Orgânicos/genética; Polimorfismo de Nucleotídeo Único; Fatores de Risco; Receptores de Sulfonilureias/genética; Proteinopatias TDP-43/metabolismo; Proteinopatias TDP-43/patologia; Tiroxina/análise; Tiroxina/genética; Tiroxina/metabolismo; Tri-Iodotironina/análise; Tri-Iodotironina/genética; Tri-Iodotironina/metabolismo

Palavras-chave

Dementia; GRN; Neuropathology; SLCO1A2; SNP; ScanScope; TMEM106B

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiroxina / Tri-Iodotironina / Encéfalo / Proteinopatias TDP-43 Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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