Oral pre-administration of Purslane polysaccharides enhance immune responses to inactivated foot-and-mouth disease vaccine in mice.
BMC Vet Res
; 15(1): 38, 2019 Jan 25.
Article
em En
| MEDLINE
| ID: mdl-30683105
ABSTRACT
BACKGROUND:
Foot-and-mouth disease (FMD) is one of the greatest disease threats to animal husbandry worldwide. Though various vaccines against foot-and-mouth disease virus (FMDV) have been developed, vaccine effectiveness is still not satisfactory. In this work, we studied the potential ability of Purslane polysaccharide (POL-P3b) as a nutrient food additive to enhance immune responses to FMD vaccination in mice.RESULTS:
Our results demonstrated that oral administration of POL-P3b at mid- and high-doses significantly enhanced the FMDV-specific cellular and humoral immune responses in mice and increased the concentration of Ca2+ in lymphocytes. Importantly, POL-P3b could promote intestinal DC maturation and stimulate the secretion of intestinal SIgA in a dose-dependent manner. Moreover, the acute toxicity study showed that POL-P3b was non-toxic and safe in mice.CONCLUSION:
Our findings provided solid evidence that POL-P3b might be a novel immunostimulator and a boosting agent for increasing the efficacy of FMD vaccination, and the mechanism was related to stimulating the intestinal mucosal immune function that subsequently enhanced the efficacy of FMD vaccination through pre-administration of oral POL-P3b.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos
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Vacinas Virais
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Vírus da Febre Aftosa
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Mucosa Intestinal
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article