Hydrophobicity-oriented drug design (HODD) of new human 4-hydroxyphenylpyruvate dioxygenase inhibitors.

Ndikuryayo, Ferdinand; Kang, Wei-Ming; Wu, Feng-Xu; Yang, Wen-Chao; Yang, Guang-Fu

Ndikuryayo, Ferdinand; Kang, Wei-Ming; Wu, Feng-Xu; Yang, Wen-Chao; Yang, Guang-Fu.

Afiliação

Ndikuryayo F; Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, Chemical Biology Center, College of Chemistry, Central China Normal University, Wuhan, 430079, PR China.
Kang WM; Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, Chemical Biology Center, College of Chemistry, Central China Normal University, Wuhan, 430079, PR China.
Wu FX; Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, Chemical Biology Center, College of Chemistry, Central China Normal University, Wuhan, 430079, PR China.
Yang WC; Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, Chemical Biology Center, College of Chemistry, Central China Normal University, Wuhan, 430079, PR China. Electronic address: tomyang@mail.
Yang GF; Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, Chemical Biology Center, College of Chemistry, Central China Normal University, Wuhan, 430079, PR China; Collaborative Innovation Center o

Eur J Med Chem ; 166: 22-31, 2019 Mar 15.

Article em En | MEDLINE | ID: mdl-30684868

Assuntos

4-Hidroxifenilpiruvato Dioxigenase/antagonistas & inibidores; Cicloexanonas/farmacologia; Desenho de Fármacos; Inibidores Enzimáticos/farmacologia; Nitrobenzoatos/farmacologia; 4-Hidroxifenilpiruvato Dioxigenase/química; 4-Hidroxifenilpiruvato Dioxigenase/metabolismo; Domínio Catalítico; Cicloexanonas/química; Cicloexanonas/metabolismo; Inibidores Enzimáticos/química; Inibidores Enzimáticos/metabolismo; Humanos; Interações Hidrofóbicas e Hidrofílicas; Simulação de Acoplamento Molecular; Nitrobenzoatos/química; Nitrobenzoatos/metabolismo; Relação Estrutura-Atividade

Palavras-chave

4-Hydroxyphenylpyruvate dioxygenase; Alkaptonuria; Hawkinisinuria; Hydrophobicity-oriented drug design (HODD); Inhibitors; Type I tyrosinemia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Cicloexanonas / Inibidores Enzimáticos / 4-Hidroxifenilpiruvato Dioxigenase / Nitrobenzoatos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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