Conversion of Ca2+ oscillation into propagative electrical signals by Ca2+-activated ion channels and connexin as a reconstituted Ca2+ clock model for the pacemaker activity.

Saeki, Takanori; Kimura, Taisuke; Hashidume, Keigo; Murayama, Takashi; Yamamura, Hisao; Ohya, Susumu; Suzuki, Yoshiaki; Nakayama, Shinsuke; Imaizumi, Yuji

Conversion of Ca²⁺ oscillation into propagative electrical signals by Ca²⁺-activated ion channels and connexin as a reconstituted Ca²⁺ clock model for the pacemaker activity.

Saeki, Takanori; Kimura, Taisuke; Hashidume, Keigo; Murayama, Takashi; Yamamura, Hisao; Ohya, Susumu; Suzuki, Yoshiaki; Nakayama, Shinsuke; Imaizumi, Yuji.

Afiliação

Saeki T; Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabedori, Mizuhoku, Nagoya, 467-8603, Japan.
Kimura T; Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabedori, Mizuhoku, Nagoya, 467-8603, Japan.
Hashidume K; Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabedori, Mizuhoku, Nagoya, 467-8603, Japan.
Murayama T; Department of Pharmacology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyoku, Tokyo, 113-8421, Japan.
Yamamura H; Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabedori, Mizuhoku, Nagoya, 467-8603, Japan.
Ohya S; Department of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuhoku, Nagoya, 467-8601, Japan.
Suzuki Y; Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabedori, Mizuhoku, Nagoya, 467-8603, Japan.
Nakayama S; Department of Cell Physiology, Graduate School of Medicine, Nagoya University, 65 Tsurumaicho, Showaku, Nagoya, 466-8550, Japan.
Imaizumi Y; Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabedori, Mizuhoku, Nagoya, 467-8603, Japan. Electronic address: yimaizum@phar.nagoya-cu.ac.jp.

Biochem Biophys Res Commun ; 510(2): 242-247, 2019 03 05.

Article em En | MEDLINE | ID: mdl-30686532

Assuntos

Sinalização do Cálcio; Cálcio/metabolismo; Conexina 43/metabolismo; Células Intersticiais de Cajal/metabolismo; Trocador de Sódio e Cálcio/metabolismo; Potenciais de Ação; Animais; Anoctamina-1/metabolismo; Relógios Biológicos; Células HEK293; Humanos; Íons/metabolismo; Masculino; Potenciais da Membrana; Camundongos; Camundongos Endogâmicos BALB C; Proteínas de Neoplasias/metabolismo; Oscilometria; Canal de Liberação de Cálcio do Receptor de Rianodina/metabolismo; Nó Sinoatrial/metabolismo

Palavras-chave

Ca(2+) clock; Ca(2+) signaling; ICC; ICLC; Pacemaker; RyR3; SK2 channel; TMEM16A channel; Telocyte

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cálcio / Conexina 43 / Trocador de Sódio e Cálcio / Sinalização do Cálcio / Células Intersticiais de Cajal Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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