The Pseudo Natural Product Myokinasib Is a Myosin Light Chain Kinase 1 Inhibitor with Unprecedented Chemotype.

Schneidewind, Tabea; Kapoor, Shobhna; Garivet, Guillaume; Karageorgis, George; Narayan, Rishikesh; Vendrell-Navarro, Gloria; Antonchick, Andrey P; Ziegler, Slava; Waldmann, Herbert

Schneidewind, Tabea; Kapoor, Shobhna; Garivet, Guillaume; Karageorgis, George; Narayan, Rishikesh; Vendrell-Navarro, Gloria; Antonchick, Andrey P; Ziegler, Slava; Waldmann, Herbert.

Afiliação

Schneidewind T; Max Planck Institute for Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, Dortmund 44227, Germany; Technische Universität Dortmund, Faculty of Chemistry and Chemical Biology, Otto-Hahn-Strasse 6, Dortmund 44227, Germany.
Kapoor S; Max Planck Institute for Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, Dortmund 44227, Germany.
Garivet G; Max Planck Institute for Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, Dortmund 44227, Germany.
Karageorgis G; Max Planck Institute for Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, Dortmund 44227, Germany.
Narayan R; Max Planck Institute for Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, Dortmund 44227, Germany.
Vendrell-Navarro G; Max Planck Institute for Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, Dortmund 44227, Germany.
Antonchick AP; Max Planck Institute for Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, Dortmund 44227, Germany.
Ziegler S; Max Planck Institute for Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, Dortmund 44227, Germany.
Waldmann H; Max Planck Institute for Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, Dortmund 44227, Germany; Technische Universität Dortmund, Faculty of Chemistry and Chemical Biology, Otto-Hahn-Strasse 6, Dortmund 44227, Germany. Electronic address: herbert.waldmann@mpi-dortmund.mp

Cell Chem Biol ; 26(4): 512-523.e5, 2019 04 18.

Article em En | MEDLINE | ID: mdl-30686759

Assuntos

Produtos Biológicos/química; Produtos Biológicos/farmacologia; Quinase de Cadeia Leve de Miosina/antagonistas & inibidores; Inibidores de Proteínas Quinases/química; Inibidores de Proteínas Quinases/farmacologia; Animais; Linhagem Celular; Citocinese/efeitos dos fármacos; Humanos; Camundongos; Cadeias Leves de Miosina/metabolismo; Quinase de Cadeia Leve de Miosina/metabolismo; Fosforilação/efeitos dos fármacos

Palavras-chave

biology-oriented synthesis; chemical biology; cytokinesis; cytokinesis failure; kinase inhibitor; myosin light chain kinase; natural products; pseudo natural products; small molecules

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Quinase de Cadeia Leve de Miosina / Inibidores de Proteínas Quinases Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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