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Identification and Optimization of Novel Small c-Abl Kinase Activators Using Fragment and HTS Methodologies.
Simpson, Graham L; Bertrand, Sophie M; Borthwick, Jennifer A; Campobasso, Nino; Chabanet, Julien; Chen, Susan; Coggins, Julia; Cottom, Josh; Christensen, Siegfried B; Dawson, Helen C; Evans, Helen L; Hobbs, Andrew N; Hong, Xuan; Mangatt, Biju; Munoz-Muriedas, Jordi; Oliff, Allen; Qin, Donghui; Scott-Stevens, Paul; Ward, Paris; Washio, Yoshiaki; Yang, Jingsong; Young, Robert J.
Afiliação
  • Simpson GL; Medicines Research Centre , GlaxoSmithKline R&D , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Bertrand SM; Medicines Research Centre , GlaxoSmithKline R&D , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Borthwick JA; Medicines Research Centre , GlaxoSmithKline R&D , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Campobasso N; GlaxoSmithKline R&D , 1250 South Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Chabanet J; Medicines Research Centre , GlaxoSmithKline R&D , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Coggins J; Medicines Research Centre , GlaxoSmithKline R&D , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Cottom J; GlaxoSmithKline R&D , 1250 South Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Dawson HC; Medicines Research Centre , GlaxoSmithKline R&D , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Evans HL; Medicines Research Centre , GlaxoSmithKline R&D , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Hobbs AN; Medicines Research Centre , GlaxoSmithKline R&D , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Hong X; GlaxoSmithKline R&D , 1250 South Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Mangatt B; GlaxoSmithKline R&D , 1250 South Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Munoz-Muriedas J; Medicines Research Centre , GlaxoSmithKline R&D , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Oliff A; GlaxoSmithKline R&D , 1250 South Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Qin D; Medicines Research Centre , GlaxoSmithKline R&D , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Scott-Stevens P; Medicines Research Centre , GlaxoSmithKline R&D , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Ward P; GlaxoSmithKline R&D , 1250 South Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Washio Y; Medicines Research Centre , GlaxoSmithKline R&D , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Yang J; GlaxoSmithKline R&D , 1250 South Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Young RJ; Medicines Research Centre , GlaxoSmithKline R&D , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
J Med Chem ; 62(4): 2154-2171, 2019 02 28.
Article em En | MEDLINE | ID: mdl-30689376
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Tiazóis / Proteínas Proto-Oncogênicas c-abl / Inibidores de Proteínas Quinases Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Tiazóis / Proteínas Proto-Oncogênicas c-abl / Inibidores de Proteínas Quinases Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article