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Selective pharmacological inhibitors of HDAC6 reveal biochemical activity but functional tolerance in cancer models.
Depetter, Yves; Geurs, Silke; De Vreese, Rob; Goethals, Sophie; Vandoorn, Elien; Laevens, Alien; Steenbrugge, Jonas; Meyer, Evelyne; de Tullio, Pascal; Bracke, Marc; D'hooghe, Matthias; De Wever, Olivier.
Afiliação
  • Depetter Y; SynBioC Research Group, Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.
  • Geurs S; Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
  • De Vreese R; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
  • Goethals S; SynBioC Research Group, Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.
  • Vandoorn E; SynBioC Research Group, Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.
  • Laevens A; Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
  • Steenbrugge J; Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
  • Meyer E; Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
  • de Tullio P; Laboratory of Biochemistry, Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
  • Bracke M; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
  • D'hooghe M; Laboratory of Biochemistry, Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
  • De Wever O; Center for Interdisciplinary Research on Medicines (CIRM), Metabolomics Group, Université de Liège, Liège, Belgium.
Int J Cancer ; 145(3): 735-747, 2019 08 01.
Article em En | MEDLINE | ID: mdl-30694564
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Histona Desacetilases / Desacetilase 6 de Histona / Neoplasias Tipo de estudo: Clinical_trials Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Histona Desacetilases / Desacetilase 6 de Histona / Neoplasias Tipo de estudo: Clinical_trials Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article