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Sex differences in aggression: Differential roles of 5-HT2, neuropeptide F and tachykinin.
Bubak, Andrew N; Watt, Michael J; Renner, Kenneth J; Luman, Abigail A; Costabile, Jamie D; Sanders, Erin J; Grace, Jaime L; Swallow, John G.
Afiliação
  • Bubak AN; Department of Neurology, University of Colorado-Anschutz Medical Campus, Aurora, Colorado, United States of America.
  • Watt MJ; Center for Brain and Behavior Research, Basic Biomedical Sciences, University of South Dakota, Vermillion, South Dakota, United States of America.
  • Renner KJ; Biology Department, University of South Dakota, Vermillion, South Dakota, United States of America.
  • Luman AA; Department of Integrative Biology, University of Colorado-Denver, Denver, United States of America.
  • Costabile JD; Department of Integrative Biology, University of Colorado-Denver, Denver, United States of America.
  • Sanders EJ; Department of Integrative Biology, University of Colorado-Denver, Denver, United States of America.
  • Grace JL; Department of Biology, Bradley University, Peoria, Illinois, United States of America.
  • Swallow JG; Department of Integrative Biology, University of Colorado-Denver, Denver, United States of America.
PLoS One ; 14(1): e0203980, 2019.
Article em En | MEDLINE | ID: mdl-30695038
Despite the conserved function of aggression across taxa in obtaining critical resources such as food and mates, serotonin's (5-HT) modulatory role on aggressive behavior appears to be largely inhibitory for vertebrates but stimulatory for invertebrates. However, critical gaps exist in our knowledge of invertebrates that need to be addressed before definitively stating opposing roles for 5-HT and aggression. Specifically, the role of 5-HT receptor subtypes are largely unknown, as is the potential interactive role of 5-HT with other neurochemical systems known to play a critical role in aggression. Similarly, the influence of these systems in driving sex differences in aggressive behavior of invertebrates is not well understood. Here, we investigated these questions by employing complementary approaches in a novel invertebrate model of aggression, the stalk-eyed fly. A combination of altered social conditions, pharmacological manipulation and 5-HT2 receptor knockdown by siRNA revealed an inhibitory role of this receptor subtype on aggression. Additionally, we provide evidence for 5-HT2's involvement in regulating neuropeptide F activity, a suspected inhibitor of aggression. However, this function appears to be stage-specific, altering only the initiation stage of aggressive conflicts. Alternatively, pharmacologically increasing systemic concentrations of 5-HT significantly elevated the expression of the neuropeptide tachykinin, which did not affect contest initiation but instead promoted escalation via production of high intensity aggressive behaviors. Notably, these effects were limited solely to males, with female aggression and neuropeptide expression remaining unaltered by any manipulation that affected 5-HT. Together, these results demonstrate a more nuanced role for 5-HT in modulating aggression in invertebrates, revealing an important interactive role with neuropeptides that is more reminiscent of vertebrates. The sex-differences described here also provide valuable insight into the evolutionary contexts of this complex behavior.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Comportamento Animal / Caracteres Sexuais / Agressão / Dípteros Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Comportamento Animal / Caracteres Sexuais / Agressão / Dípteros Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article