Acute Traumatic Brain Injury Induces CD4+ and CD8+ T Cell Functional Impairment by Upregulating the Expression of PD-1 via the Activated Sympathetic Nervous System.

Yang, Yongxiang; Ye, Yuqin; Chen, Chen; Kong, Chuiguang; Su, Xinhong; Zhang, Xin; Bai, Wei; He, Xiaosheng

Yang, Yongxiang; Ye, Yuqin; Chen, Chen; Kong, Chuiguang; Su, Xinhong; Zhang, Xin; Bai, Wei; He, Xiaosheng.

Afiliação

Yang Y; Department of Neurosurgery, Xijing Hospital, Airforce Military Medical University (Fourth Military Medical University), Xi'an, China.
Ye Y; Department of Neurosurgery, PLA 422nd Hospital, Zhanjiang, China.
Chen C; Department of Neurosurgery, Xijing Hospital, Airforce Military Medical University (Fourth Military Medical University), Xi'an, China.
Kong C; Department of Neurosurgery, PLA 163rd Hospital (Second Affiliated Hospital of Hunan Normal University), Changsha, China.
Su X; Institute of Psychology, Airforce Military Medical University (Fourth Military Medical University), Xi'an, China.
Zhang X; Department of Neurosurgery, Xijing Hospital, Airforce Military Medical University (Fourth Military Medical University), Xi'an, China.
Bai W; Department of Neurosurgery, Xijing Hospital, Airforce Military Medical University (Fourth Military Medical University), Xi'an, China.
He X; Department of Neurosurgery, Xijing Hospital, Airforce Military Medical University (Fourth Military Medical University), Xi'an, China.

Neuroimmunomodulation ; 26(1): 43-57, 2019.

Article em En | MEDLINE | ID: mdl-30695785

Assuntos

Contusão Encefálica/imunologia; Linfócitos T CD4-Positivos/imunologia; Linfócitos T CD8-Positivos/imunologia; Tolerância Imunológica/imunologia; Norepinefrina/metabolismo; Receptor de Morte Celular Programada 1/imunologia; Sistema Nervoso Simpático/imunologia; Antagonistas Adrenérgicos beta/farmacologia; Animais; Lesões Encefálicas Traumáticas/imunologia; Linfócitos T CD4-Positivos/efeitos dos fármacos; Linfócitos T CD8-Positivos/efeitos dos fármacos; Citometria de Fluxo; Interferon gama/imunologia; Leucócitos Mononucleares/imunologia; Receptor de Morte Celular Programada 1/efeitos dos fármacos; Propranolol/farmacologia; Ratos; Sistema Nervoso Simpático/efeitos dos fármacos; Fator de Necrose Tumoral alfa/imunologia; Regulação para Cima

Palavras-chave

Norepinephrine; Programmed cell death-1; Sympathetic nervous system; T cell dysfunction; Traumatic brain injury

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistema Nervoso Simpático / Linfócitos T CD4-Positivos / Norepinefrina / Linfócitos T CD8-Positivos / Receptor de Morte Celular Programada 1 / Contusão Encefálica / Tolerância Imunológica Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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